Endocrine Abstracts

Introduction: Phaeochromocytomas often induce hyperglycaemia. Few cases are reported with hypoglycaemic fits. The mechanism is unknown. Our findings may indicate a mechanism.The patient: A 37 year old female had a phaeochromocytoma, with typical characteristics: attacks of headache, nausea and sweating. High blood pressures, up to 237/134. Electrocardiogram indicated ischemia, normal coronary arteries on dynamic CT, normal Echo-Doppler heart examination....

Background: We have previously shown that LC-MS/MS analyses of steroid hormones are superior to immunoassays monitoring 21OHD, due to better specificity and the possibility to multiplexing several steroid hormones in the same assay. This may lead to better understanding of the individual steroid hormone profile in patients with CAH. Here we present four patients cases with the same genotype in the CYP21A2 gene, and evaluate their steroid profile by LC-MS/MS analyses.<...

BackgroundNon-classical congenial adrenal hyperplasia (NCCAH) is an important differential diagnosis in women with acne, hirsutism, menstrual abnormalities and infertility. To diagnose NCCAH can be challenging, and currently used cutoff levels are based on unstandardized immunological assays, no longer in use.ObjectiveDefine LC-MS/MS based cut-off levels for steroid hormones, to improve diagnosis of NCCAH and...